If you really have to design your pages for a specific resolution, it's safe to go with 1024x768 anymore, but if you want to include people with really old computers still using CRT monitors etc, stick with 800x600. (I think the conventional wisdom is that about 5 to 7% are still using 800x600)
However, you should be using relative DIVs and percentage widths to create a page that will collapse a
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