Current Powerball pre-tax lump sum is $43.3 million, current Megamillions pre-tax lump sum is $60.4 million:
http://www.powerball.com/pb_home.asp
http://www.megamillions.com/
The total fed+(VA)state tax rate for such a lump sum is about 40.75%, plus or minus - that is, you get to keep, after all is said and done, about 59.25% of the lump sum, plus or minus (Virginia takes an immediate 28% before you get anything, but you're still on the hook for the rest of the taxes at tax time).
So your in-the-pocket bucks after getting hit with taxes is about $25.5 million for the current Powerball and about $35.5 million for the current Megamillions, noise level change ignored.
Either one of those buckets of cash place you in the "uber wealthy" category, I believe (which I think someone somewhere defines as starting at about $30 million in assets).
So...the SECOND thing you do - and you should ALREADY have done it if you buy lottery tickets - is to Google for "What do you do if you win the lottery"...there are LOTS of useful links off such a search, including at least a few to books on what to do if you are suddenly wealthy!
The FIRST thing you do, of course, is sign the lottery ticket, make (digital) copies of front of back, distribute those copies to more than one remote site, make hardcopies of front and back, and put the ticket in a safe deposit box IMMEDIATELY.
You do NOT tell friends or relatives (other than spouse) ANYTHING.
Then you contact an Asset Protection Attorney and arrange a fee-only use of that attorney's services. Same applies to Financial Planner(s). In each case, the people you contract with should be familiar/experienced with handling the affairs of the uber-wealthy - the CPA/FP you use for your current taxes is probably NOT the one you want to use anymore since you are now in an entirely different financial world.
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Since you're going to be signing VERY costly contracts with the above, you should retain an attorney who will be used simply to review and approve those and other contracts BEFORE you sign them.
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Either of the two dollar amounts mentioned above should EASILY earn MUCH more than a million dollars (pre-tax) per year WITHOUT touching the principal amount.
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After you have collected the bucks and stashed MOST of it away in safe havens as decided by your asset protection attorney and financial planner, you should plan on spending about 10% for anything at all. The theory with this is - hey! You may die tomorrow! Spend while you can and ENJOY that winning as if there literally is no tomorrow! Party party party!
Your steady state income will be relatively huge - think about how that income will be used. Think of what your most valuable asset is - typically "time" to most people - and use that income to save you the most time. You and your spouse, for example, are rather unlikely to do any laundry, cleaning, most shopping, possibly driving, just about any of the day-to-day tasks that non-uber-wealthy folks have to do.
The odds of winning are way against anyone - but if you DO win, do it right.
[I'm thinking of that poor winner who got himself murdered because he pretty much continued to live his former life, including former "friend" type...bad move!]